Highlights•Publications for drug repositioning have drastically increased in past five
years.•Different types of drug repositioning and available resources have been …

Malaria is a devastating infectious disease that is caused by blood-borne apicomplexan
parasites of the genus Plasmodium. These pathogens have a complex lifecycle, which …

In response to the current global health emergency posed by the Zika virus (ZIKV) outbreak
and its link to microcephaly and other neurological conditions, we performed a drug …

A major cause of the paucity of new starting points for drug discovery is the lack of
interaction between academia and industry. Much of the global resource in biology is …

Drug affinity responsive target stability (DARTS) is a relatively quick and straightforward
approach to identify potential protein targets for small molecules. It relies on the protection …

Despite decades of research, little is known about the cellular targets and the mode of action
of the vast majority of antimalarial drugs. We recently demonstrated that the cellular thermal …

Preventing transmission is an important element of malaria control. However, most of the
current available methods to assay for malaria transmission blocking are relatively low …

Preventing human-to-mosquito transmission of malaria parasites provides possible
solutions to interrupt the malaria parasite life cycle for malaria elimination. The development …

Departing from conventional narratives of the United States and the Americas as
fundamentally continental spaces, the contributors to Archipelagic American Studies …

The threat of widespread drug resistance to frontline antimalarials has renewed the urgency
for identifying inexpensive chemotherapeutic compounds that are effective against …