[HTML][HTML] Chromatin and aberrant enhancer activity in KMT2A rearranged acute lymphoblastic leukemia
TA Milne - Current Opinion in Genetics & Development, 2024 - Elsevier
Highlights•Enhancer function in normal cells and disease is still not fully understood.•Protein
complexes drive enhancer-promoter proximity.•MLL rearranged leukemias assemble …
complexes drive enhancer-promoter proximity.•MLL rearranged leukemias assemble …
SEC: A core hub during cell fate alteration
Z Zhang, J Xu, J Liu, J Wang, L Lei - The FASEB Journal, 2024 - Wiley Online Library
Pol II pause release is a rate‐limiting step in gene transcription, influencing various cell fate
alterations. Numerous proteins orchestrate Pol II pause release, thereby playing pivotal …
alterations. Numerous proteins orchestrate Pol II pause release, thereby playing pivotal …