Highly active antiretroviral therapy (HAART) regimes based on nucleoside reverse
transcriptase inhibitors (NRTIs) have revolutionized the treatment of AIDS in recent years …

The available informations on the genotoxic effects in experimental systems of the
antiherpesvirus nucleosides aciclovir, penciclovir, ganciclovir, brivudine and cidofovir as …

Mitochondrial toxicity can result from antiviral nucleotide analog therapy used to control
human immunodeficiency virus type 1 infection. We evaluated the ability of such analogs to …

Nucleoside analogs were first approved by the US Food and Drug Administration for use
against HIV‐AIDS in 1987. Since then, these agents, now commonly referred to as …

The era of highly active antiretroviral therapy (HAART) has controlled AIDS and its related
disorders considerably; however, the prevalence of HIV-1-associated neurocognitive …

We report the activities of a novel nucleoside analog against HIV. This nucleoside (KP-1212)
is not a chain terminator but exerts its antiviral effects via mutagenesis of the viral genome …

In this work, we elucidated some key aspects of the mechanism of action of the cisplatin
anticancer drug, cis-[Pt (NH3) 2Cl2], involving direct interactions with free nucleotides. A …

The current worldwide spread of the human immunodeficiency virus-1 (HIV-1) to the
heterosexual population has resulted in approximately 800000 children born yearly to HIV-1 …

Nucleoside analogues represent the cornerstones of antiretroviral regimens. A range of drug-
or tissue-specific toxicities, such as peripheral neuropathy, myopathy, pancreatitis and lactic …

Nucleoside analogs are associated with various mitochondrial toxicities, and it is becoming
increasingly difficult to accommodate these differences solely in the context of DNA …