[HTML][HTML] Obesity and type 2 diabetes mellitus: Connections in epidemiology, pathogenesis, and treatments

R Ruze, T Liu, X Zou, J Song, Y Chen, R Xu… - Frontiers in …, 2023 - frontiersin.org
The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …

Browning of the white adipose tissue regulation: New insights into nutritional and metabolic relevance in health and diseases

SA Machado, G Pasquarelli-do-Nascimento… - Nutrition & …, 2022 - Springer
Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

[PDF][PDF] Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue

M Rosina, V Ceci, R Turchi, C Li, N Borcherding… - Cell metabolism, 2022 - cell.com
Recent findings have demonstrated that mitochondria can be transferred between cells to
control metabolic homeostasis. Although the mitochondria of brown adipocytes comprise a …

Metabolic flexibility as an adaptation to energy resources and requirements in health and disease

RL Smith, MR Soeters, RCI Wüst… - Endocrine …, 2018 - academic.oup.com
The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

Aggregation-induced emission: together we shine, united we soar!

J Mei, NLC Leung, RTK Kwok, JWY Lam… - Chemical …, 2015 - ACS Publications
Light is of essential importance to the universe and humankind. Light has been, and
continues to be, one of the most fundamental and indispensable elements to life and society …

[HTML][HTML] Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

P Lee, JD Linderman, S Smith, RJ Brychta, J Wang… - Cell metabolism, 2014 - cell.com
Rediscovery of cold-activated brown adipose tissue (BAT) in humans has boosted research
interest in identifying BAT activators for metabolic benefits. Of particular interest are …

Brown and beige adipose tissue and aging

E Zoico, S Rubele, A De Caro, N Nori… - Frontiers in …, 2019 - frontiersin.org
Across aging, adipose tissue (AT) changes its quantity and distribution: AT becomes
dysfunctional with an increase in production of inflammatory peptides, a decline of those …

White, brown, beige/brite: different adipose cells for different functions?

M Giralt, F Villarroya - Endocrinology, 2013 - academic.oup.com
Brown adipose tissue (BAT) is a major site of nonshivering thermogenesis in mammals.
Rodent studies indicated that BAT thermogenic activity may protect against obesity. Recent …

Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans

P Lee, S Smith, J Linderman, AB Courville… - Diabetes, 2014 - Am Diabetes Assoc
In rodents, brown adipose tissue (BAT) regulates cold-and diet-induced thermogenesis (CIT;
DIT). Whether BAT recruitment is reversible and how it impacts on energy metabolism have …

[HTML][HTML] Molecular mechanisms of adipogenesis: the anti-adipogenic role of AMP-activated protein kinase

B Ahmad, CJ Serpell, IL Fong… - Frontiers in molecular …, 2020 - frontiersin.org
Obesity is now a widespread disorder, and its prevalence has become a critical concern
worldwide, due to its association with common co-morbidities like cancer, cardiovascular …