Lung cancer is the leading cause of cancer-related mortality not only in the United States but
also around the world. In North America, lung cancer has become more predominant among …

This review deals with germ-line genes that increase susceptibility to five major types of
cancer: breast, lung, pancreatic, prostate, and colorectal cancer. Often familial, often …

Determining the genetic basis of cancer requires comprehensive analyses of large
collections of histopathologically well-classified primary tumours. Here we report the results …

Objective: A recent study provisionally identified numerous genetic variants as risk factors for
the transition from smoking to the development of nicotine dependence, including an amino …

Uncertainty about the phase of strings of SNPs creates complications in genetic analysis,
although methods have been developed for phasing population-based samples. However …

We conducted a genome-wide association (GWA) study of lung cancer comparing 511,919
SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was …

We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159
controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated …

We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer
(UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in …

People who begin daily smoking at an early age are at greater risk of long-term nicotine
addiction. We tested the hypothesis that associations between nicotinic acetylcholine …

Genome-wide association studies (GWAS) provide a powerful approach to identify common,
low-penetrance disease loci without prior knowledge of location or function. GWAS have …