Genotype imputation is now an essential tool in the analysis of genome-wide association
scans. This technique allows geneticists to accurately evaluate the evidence for association …

Nicotinic receptors—a family of ligand-gated ion channels that mediate the effects of the
neurotransmitter acetylcholine—are among the most well understood allosteric membrane …

There is considerable variability in the susceptibility of smokers to develop chronic
obstructive pulmonary disease (COPD). The only known genetic risk factor is severe …

The normal functioning of p53 is a potent barrier to cancer. Tumour-associated mutations in
TP53, typically single nucleotide substitutions in the coding sequence, are a hallmark of …

Three genetic loci for lung cancer risk have been identified by genome-wide association
studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not …

The common sequence variants that have recently been associated with cancer risk are
particular to a single cancer type or at most two. Following up on our genome-wide scan of …

The causes of glioblastoma and other gliomas remain obscure,. To discover new candidate
genes influencing glioma susceptibility, we conducted a principal component–adjusted …

High-throughput technologies for DNA sequencing and for analyses of transcriptomes,
proteomes and metabolomes have provided the foundations for deciphering the structure …

Cigarette smoking is strongly correlated with the onset of nonsmall cell lung cancer
(NSCLC). Nicotine, an active component of cigarettes, has been found to induce …

In humans, tobacco withdrawal produces symptoms that contribute to the difficulty
associated with smoking cessation. Nicotine withdrawal symptoms can also be observed in …