This review gives an account of the cigarette as a highly efficient nicotine delivery system. It
explains how nicotine induces pleasure, reduces stress and anxiety, and causes addiction …

Rapid technical advances in DNA sequencing and genome-wide association studies are
driving the discovery of the germline and somatic mutations that are present in different …

Smoking is a common risk factor for many diseases. We conducted genome-wide
association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers …

Smoking is a leading global cause of disease and mortality. We established the Oxford-
GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP …

Recently, genetic association findings for nicotine dependence, smoking behavior, and
smoking-related diseases converged to implicate the chromosome 15q25. 1 region, which …

Tobacco smoking is an extremely addictive and harmful form of nicotine (NIC) consumption,
but unfortunately also the most prevalent. Although disproportionately high frequencies of …

Background Lung cancer in individuals who have never smoked tobacco products is an
increasing medical and public-health issue. We aimed to unravel the genetic basis of lung …

There has been much recent interest in the role of the vitamin D axis in lung disease, which
includes vitamin D, vitamin D receptor (VDR) and vitamin D-binding protein (VDBP; also …

This Timeline article looks back at 40 years of research into the inherited genetic basis of
cancer and the insights these studies have yielded. Early epidemiological research provided …

It is now 5 years since the first genome-wide association studies (GWAS), published in 2005,
identified a common risk allele with large effect size for age-related macular degeneration in …