Non-small-cell lung cancer

P Goldstraw, D Ball, JR Jett, T Le Chevalier, E Lim… - The Lancet, 2011 - thelancet.com
In the decade since the last Lancet Seminar on lung cancer there have been advances in
many aspects of the classification, diagnosis, and treatment of non-small-cell lung cancer …

Molecular biology of lung cancer: clinical implications

JE Larsen, JD Minna - Clinics in chest medicine, 2011 - chestmed.theclinics.com
Lung cancer is the leading cause of cancer-related death in men and women in the United
States, accounting for approximately 28% of total cancer deaths in 2010 despite comprising …

Habenular α5 nicotinic receptor subunit signalling controls nicotine intake

CD Fowler, Q Lu, PM Johnson, MJ Marks, PJ Kenny - Nature, 2011 - nature.com
Genetic variation in CHRNA5, the gene encoding the α5 nicotinic acetylcholine receptor
subunit, increases vulnerability to tobacco addiction and lung cancer, but the underlying …

A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12. 12 and 22q12. 2 in Han Chinese

Z Hu, C Wu, Y Shi, H Guo, X Zhao, Z Yin, L Yang… - Nature …, 2011 - nature.com
Lung cancer is the leading cause of cancer-related deaths worldwide. To identify genetic
factors that modify the risk of lung cancer in individuals of Chinese ancestry, we performed a …

Lung cancer risk prediction: prostate, lung, colorectal and ovarian cancer screening trial models and validation

CM Tammemagi, PF Pinsky… - Journal of the …, 2011 - academic.oup.com
Introduction Identification of individuals at high risk for lung cancer should be of value to
individuals, patients, clinicians, and researchers. Existing prediction models have only …

[HTML][HTML] East meets West: ethnic differences in epidemiology and clinical behaviors of lung cancer between East Asians and Caucasians

W Zhou, DC Christiani - Chinese Journal of Cancer, 2011 - ncbi.nlm.nih.gov
Lung cancer is the leading cause of cancer death worldwide, with large variation of the
incidence and mortality across regions. Although the mortality of lung cancer has been …

Epidemiology, epigenetics and the 'Gloomy Prospect': embracing randomness in population health research and practice

GD Smith - International journal of epidemiology, 2011 - academic.oup.com
Epidemiologists aim to identify modifiable causes of disease, this often being a prerequisite
for the application of epidemiological findings in public health programmes, health service …

Chronic obstructive pulmonary disease and lung cancer: new molecular insights

IM Adcock, G Caramori, PJ Barnes - Respiration, 2011 - karger.com
Both chronic obstructive pulmonary disease (COPD) and lung cancer are major causes of
death worldwide. In most cases this reflects cigarette smoke exposure which is able to …

Genetics of lung-cancer susceptibility

P Brennan, P Hainaut, P Boffetta - The lancet oncology, 2011 - thelancet.com
Lung cancer is the most common form of cancer death worldwide. Although reduction of
tobacco consumption remains the most appropriate strategy to reduce lung-cancer burden …

A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium

JD McKay, T Truong, V Gaborieau, A Chabrier… - PLoS …, 2011 - journals.plos.org
Genome-wide association studies (GWAS) have been successful in identifying common
genetic variation involved in susceptibility to etiologically complex disease. We conducted a …