Lung carcinogenesis by tobacco smoke

SS Hecht - International journal of cancer, 2012 - Wiley Online Library
Cigarette smoke is a complex mixture of chemicals including multiple genotoxic lung
carcinogens. The classic mechanisms of carcinogen metabolic activation to DNA adducts …

Lung cancer epidemiology, risk factors, and prevention

P de Groot, RF Munden - Radiologic Clinics, 2012 - radiologic.theclinics.com
Carcinoma of the lung is currently the leading cause worldwide of death due to cancer. The
disease has become an epidemic as incidence rates and lung cancer deaths have risen …

The genetic basis of addictive disorders

F Ducci, D Goldman - Psychiatric Clinics, 2012 - psych.theclinics.com
• Genetic and environmental influences modulating risk of substance use disorders change
developmentally and across the lifespan.• Genes involved in vulnerability to addictions …

Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia

Q Lan, CA Hsiung, K Matsuo, YC Hong, A Seow… - Nature …, 2012 - nature.com
To identify common genetic variants that contribute to lung cancer susceptibility, we
conducted a multistage genome-wide association study of lung cancer in Asian women who …

Lung cancer screening

DE Wood, GA Eapen, DS Ettinger, L Hou… - Journal of the National …, 2012 - jnccn.org
Lung Cancer Screening in: Journal of the National Comprehensive Cancer Network Volume
10 Issue 2 (2012) Jump to Content User Account Sign In to save searches and organize your …

The genetics of addiction—a translational perspective

A Agrawal, KJH Verweij, NA Gillespie, AC Heath… - Translational …, 2012 - nature.com
Addictions are serious and common psychiatric disorders, and are among the leading
contributors to preventable death. This selective review outlines and highlights the need for …

Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls

MN Timofeeva, RJ Hung, T Rafnar… - Human molecular …, 2012 - academic.oup.com
Recent genome-wide association studies (GWASs) have identified common genetic variants
at 5p15. 33, 6p21–6p22 and 15q25. 1 associated with lung cancer risk. Several other …

[HTML][HTML] Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium

ML Coté, M Liu, S Bonassi, M Neri, AG Schwartz… - European journal of …, 2012 - Elsevier
BACKGROUND AND METHODS: Familial aggregation of lung cancer exists after
accounting for cigarette smoking. However, the extent to which family history affects risk by …

Genome-Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow Obstruction

JB Wilk, NRG Shrine, LR Loehr, JH Zhao… - American journal of …, 2012 - atsjournals.org
Rationale: Genome-wide association studies (GWAS) have identified loci influencing lung
function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are …

Predictive accuracy of the Liverpool Lung Project risk model for stratifying patients for computed tomography screening for lung cancer: a case–control and cohort …

OY Raji, SW Duffy, OF Agbaje, SG Baker… - Annals of internal …, 2012 - acpjournals.org
Background: External validation of existing lung cancer risk prediction models is limited.
Using such models in clinical practice to guide the referral of patients for computed …