Pleiotropy in complex traits: challenges and strategies
Genome-wide association studies have identified many variants that each affects multiple
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …
Epidemiology of lung cancer: Diagnosis and management of lung cancer: American College of Chest Physicians evidence-based clinical practice guidelines
AJ Alberg, MV Brock, JG Ford, JM Samet, SD Spivack - Chest, 2013 - Elsevier
Background Ever since a lung cancer epidemic emerged in the mid-1900s, the
epidemiology of lung cancer has been intensively investigated to characterize its causes …
epidemiology of lung cancer has been intensively investigated to characterize its causes …
Cohort profile: the HUNT study, Norway
S Krokstad, A Langhammer, K Hveem… - International journal …, 2013 - academic.oup.com
The HUNT Study includes large total population-based cohorts from the 1980ies, covering
125 000 Norwegian participants; HUNT1 (1984-86), HUNT2 (1995-97) and HUNT3 (2006 …
125 000 Norwegian participants; HUNT1 (1984-86), HUNT2 (1995-97) and HUNT3 (2006 …
Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease
DN Cooper, M Krawczak, C Polychronakos… - Human genetics, 2013 - Springer
Some individuals with a particular disease-causing mutation or genotype fail to express
most if not all features of the disease in question, a phenomenon that is known as 'reduced …
most if not all features of the disease in question, a phenomenon that is known as 'reduced …
Mechanistic links between COPD and lung cancer
AMG Houghton - Nature Reviews Cancer, 2013 - nature.com
Numerous epidemiological studies have consistently linked the presence of chronic
obstructive pulmonary disease (COPD) to the development of lung cancer, independently of …
obstructive pulmonary disease (COPD) to the development of lung cancer, independently of …
A three-way decomposition of a total effect into direct, indirect, and interactive effects
TJ VanderWeele - Epidemiology, 2013 - journals.lww.com
Recent theory in causal inference has provided concepts for mediation analysis and effect
decomposition that allow one to decompose a total effect into a direct and an indirect effect …
decomposition that allow one to decompose a total effect into a direct and an indirect effect …
Lung cancer in never smokers: disease characteristics and risk factors
AG Pallis, KN Syrigos - Critical reviews in oncology/hematology, 2013 - Elsevier
It is estimated that approximately 25% of all lung cancer cases are observed in never-
smokers and its incidence is expected to increase due to smoking prevention programs …
smokers and its incidence is expected to increase due to smoking prevention programs …
Molecular mechanisms underlying behaviors related to nicotine addiction
MR Picciotto, PJ Kenny - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
Tobacco smoking results in more than 5 million deaths each year and accounts for almost
90% of all deaths from lung cancer. Nicotine, the major reinforcing component of tobacco …
90% of all deaths from lung cancer. Nicotine, the major reinforcing component of tobacco …
[HTML][HTML] 1B50-1, a mAb raised against recurrent tumor cells, targets liver tumor-initiating cells by binding to the calcium channel α2δ1 subunit
W Zhao, L Wang, H Han, K Jin, N Lin, T Guo, Y Chen… - Cancer cell, 2013 - cell.com
The identification and targeted therapy of cells involved in hepatocellular carcinoma (HCC)
recurrence remain challenging. Here, we generated a monoclonal antibody against …
recurrence remain challenging. Here, we generated a monoclonal antibody against …
Neuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence
LM Hendrickson, MJ Guildford, AR Tapper - Frontiers in psychiatry, 2013 - frontiersin.org
Alcohol and nicotine are often co-abused. As many as 80–95% of alcoholics are also
smokers, suggesting that ethanol and nicotine, the primary addictive component of tobacco …
smokers, suggesting that ethanol and nicotine, the primary addictive component of tobacco …