Genome-wide association studies have identified many variants that each affects multiple
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …

Background Ever since a lung cancer epidemic emerged in the mid-1900s, the
epidemiology of lung cancer has been intensively investigated to characterize its causes …

The HUNT Study includes large total population-based cohorts from the 1980ies, covering
125 000 Norwegian participants; HUNT1 (1984-86), HUNT2 (1995-97) and HUNT3 (2006 …

Some individuals with a particular disease-causing mutation or genotype fail to express
most if not all features of the disease in question, a phenomenon that is known as 'reduced …

Numerous epidemiological studies have consistently linked the presence of chronic
obstructive pulmonary disease (COPD) to the development of lung cancer, independently of …

Recent theory in causal inference has provided concepts for mediation analysis and effect
decomposition that allow one to decompose a total effect into a direct and an indirect effect …

It is estimated that approximately 25% of all lung cancer cases are observed in never-
smokers and its incidence is expected to increase due to smoking prevention programs …

Tobacco smoking results in more than 5 million deaths each year and accounts for almost
90% of all deaths from lung cancer. Nicotine, the major reinforcing component of tobacco …

The identification and targeted therapy of cells involved in hepatocellular carcinoma (HCC)
recurrence remain challenging. Here, we generated a monoclonal antibody against …

Alcohol and nicotine are often co-abused. As many as 80–95% of alcoholics are also
smokers, suggesting that ethanol and nicotine, the primary addictive component of tobacco …