Tobacco smoke contains multiple classes of established carcinogens including benzo (a)
pyrenes, polycyclic aromatic hydrocarbons, and tobacco-specific nitrosamines. Most of these …

Nicotine stimulates brain reward circuitries, most prominently the mesocorticolimbic
dopamine system, and this action plays a critical in establishing and maintaining the tobacco …

The overall effect of an exposure on an outcome, in the presence of a mediator with which
the exposure may interact, can be decomposed into 4 components:(1) the effect of the …

We conducted imputation to the 1000 Genomes Project of four genome-wide association
studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 …

The genetic regulation of the human epigenome is not fully appreciated. Here we describe
the effects of genetic variants on the DNA methylome in human lung based on methylation …

Acetylcholine (ACh) is not only a neurotransmitter but is an ancient molecule that can be
released by and act on non-neuronal cells. In these cells the system of ACh-synthesizing …

Rationale: Emphysema is a heritable trait that occurs in smokers with and without chronic
obstructive pulmonary disease. Emphysema occurs in distinct pathologic patterns, but the …

A framework is presented that allows an investigator to estimate the portion of the effect of
one exposure that is attributable to an interaction with a second exposure. We show that …

MicroRNAs (miRNAs) are post-transcriptional gene regulators that are differentially
expressed in several pathophysiological conditions including cancer. They impact the …

Smoking is a major risk factor for several somatic diseases and is also emerging as a causal
factor for neuropsychiatric disorders. Genome-wide association (GWA) and candidate gene …