Smoking-induced lung diseases were extremely rare prior to the 20th century. With
commercialization and introduction of machine-made cigarettes, worldwide use skyrocketed …

Progress in the fields of neuroscience and molecular biology has identified the forebrain
cholinergic system as being important in many higher order brain functions. Further analysis …

Lung cancer is considered an age-associated disease, whose progression is in part due to
accumulation of genomic instability as well as age-related decline in system integrity and …

Background Pulmonary function decline is a major contributor to morbidity and mortality
among smokers. Post bronchodilator FEV 1 and FEV 1/FVC ratio are considered the …

Chronic tobacco smoking is a major cause of preventable morbidity and mortality worldwide.
In the lung, tobacco smoking increases the risk of lung cancer, and also causes chronic …

Diseases associated with tobacco use constitute a major health problem worldwide. Upon
cessation of tobacco use, an unpleasant withdrawal syndrome occurs in dependent …

Background: Several subsets of non–small-cell lung cancer (NSCLC) are defined by
molecular alterations acting as tumor drivers, some of them being currently therapeutically …

Purpose Adenocarcinoma is the most dominant type of lung cancer in never-smoker
patients. The risk alleles from genome-wide association studies have small odds ratios and …

We conducted a 1000 Genomes–imputed genome-wide association study (GWAS) meta-
analysis for nicotine dependence, defined by the Fagerström Test for Nicotine Dependence …

Identification of high-risk individuals will facilitate early diagnosis, reduce overall costs, and
also improve the current poor survival from lung cancer. The Liverpool Lung Project …