Lung cancer has a poor prognosis; over half of people diagnosed with lung cancer die
within one year of diagnosis and the 5-year survival is less than 18%. Non-small cell lung …

Lung cancer continues to be one of the most common causes of cancer death despite
understanding the major cause of the disease: cigarette smoking. Smoking increases lung …

Primary lung cancer remains the most common malignancy after non-melanocytic skin
cancer, and deaths from lung cancer exceed those from any other malignancy worldwide [1] …

The worldwide obesity epidemic has been mainly attributed to lifestyle changes. However,
who becomes obese in an obesity-prone environment is largely determined by genetic …

Lifespan is a trait of enormous personal interest. Research into the biological basis of
human lifespan, however, is hampered by the long time to death. Using a novel approach of …

Genome-wide association studies (GWASs) have identified associations between the
CHRNA5–CHRNA3–CHRNB4 gene cluster and smoking heaviness and nicotine …

Cigarette smoking is the major cause of preventable death and morbidity throughout the
world. Many compounds are present in tobacco, but nicotine is the primary addictive one …

Metabolism of nicotine by cytochrome P450 2A6 (CYP2A6) is a suspected determinant of
smoking dose and, consequently, lung cancer risk. We conducted a genome-wide …

Nicotine, the primary addictive constituent of cigarettes, is believed to contribute to cancer
promotion and progression through the activation of nicotinic acetylcholine receptors …

Objectives Genome-wide association studies (GWAS) of lung cancer have identified regions
of common genetic variation with lung cancer risk in Europeans who smoke and never …