European position statement on lung cancer screening
M Oudkerk, A Devaraj, R Vliegenthart… - The Lancet …, 2017 - thelancet.com
Lung cancer screening with low-dose CT can save lives. This European Union (EU) position
statement presents the available evidence and the major issues that need to be addressed …
statement presents the available evidence and the major issues that need to be addressed …
[HTML][HTML] Familial risk for lung cancer
Lung cancer, which has a low survival rate, is a leading cause of cancer-associated mortality
worldwide. Smoking and air pollution are the major causes of lung cancer; however …
worldwide. Smoking and air pollution are the major causes of lung cancer; however …
Case–control association mapping by proxy using family history of disease
Collecting cases for case–control genetic association studies can be time-consuming and
expensive. In some situations (such as studies of late-onset or rapidly lethal diseases), it …
expensive. In some situations (such as studies of late-onset or rapidly lethal diseases), it …
Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies
J Wang, Q Liu, S Yuan, W Xie, Y Liu, Y Xiang, N Wu… - Scientific reports, 2017 - nature.com
More than 1000 candidate-gene association studies on genetic susceptibility to lung cancer
have been published over the last two decades but with few consensuses for the likely …
have been published over the last two decades but with few consensuses for the likely …
Lung cancer risk prediction model incorporating lung function: development and validation in the UK Biobank prospective cohort study
Purpose Several lung cancer risk prediction models have been developed, but none to date
have assessed the predictive ability of lung function in a population-based cohort. We …
have assessed the predictive ability of lung function in a population-based cohort. We …
Comparative transcriptome profiling reveals coding and noncoding RNA differences in NSCLC from African Americans and European Americans
KA Mitchell, A Zingone, L Toulabi, J Boeckelman… - Clinical Cancer …, 2017 - AACR
Purpose: To determine whether racial differences in gene and miRNA expression translates
to differences in lung tumor biology with clinical relevance in African Americans (AAs) and …
to differences in lung tumor biology with clinical relevance in African Americans (AAs) and …
Establishment of a strong link between smoking and cancer pathogenesis through DNA methylation analysis
Smoking is a well-documented risk factor in various cancers, especially lung cancer. In the
current study, we tested the hypothesis that abnormal DNAm loci associated with smoking …
current study, we tested the hypothesis that abnormal DNAm loci associated with smoking …
Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings …
To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among
never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified …
never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified …
When will Mendelian randomization become relevant for clinical practice and public health?
Obtaining reliable evidence regarding factors that cause disease or influence disease
progression is clearly central to progress in science. There have been many high-profile …
progression is clearly central to progress in science. There have been many high-profile …
Quantifying the genetic correlation between multiple cancer types
Background: Many cancers share specific genetic risk factors, including both rare high-
penetrance mutations and common SNPs identified through genome-wide association …
penetrance mutations and common SNPs identified through genome-wide association …