Electronic cigarettes (e-cigarettes) are alternative, non-combustible tobacco products that
generate an inhalable aerosol containing nicotine, flavors, propylene glycol, and vegetable …

Efforts to link variation in the human genome to phenotypes have progressed at a
tremendous pace in recent decades. Most human traits have been shown to be affected by a …

Quantifying the genetic correlation between cancers can provide important insights into the
mechanisms driving cancer etiology. Using genome-wide association study summary …

Acetylcholine (ACh) was first identified as a classic neuromodulator and transmit signals
through two subgroups of receptors, namely muscarinic receptors (mAChRs) and nicotinic …

The neurotransmitter acetylcholine (ACh) acts as an autocrine growth factor for human lung
cancer. Several lines of evidence show that lung cancer cells express all of the proteins …

Introduction: COPD and lung cancer are leading causes of morbidity and mortality
worldwide, and they share a common environmental risk factor in cigarette smoke exposure …

Objective Germline alterations in the breast cancer susceptibility genes type 1 and 2,
BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian …

Addiction is now recognized as a neurobiological and cognitive brain disorder and is
generally viewed as a switch from recreational or voluntary to compulsive substance use …

Abstract Knowledge of the lung cancer genome has experienced rapid growth over the past
decade. Genome-wide association studies and sequencing studies have identified dozens …

Background: The morbidity and mortality associated with tobacco smoking is well
established. Nicotine is the addictive component of tobacco. Nicotine, through the non …