Tobacco smoking results in more than five million deaths each year and accounts for∼ 90%
of all deaths from lung cancer. Nicotine, the major reinforcing component of tobacco smoke …

Lung cancer is the leading cause of cancer-related mortality globally, accounting for 1.8
million deaths in 2020. While the vast majority are caused by tobacco smoking, 15%− 25 …

Allelic variation in CHRNA3, the gene encoding the α3 nicotinic acetylcholine receptor
(nAChR) subunit, increases vulnerability to tobacco dependence and smoking-related …

Vincamine, a well-known plant alkaloid, has been used as a dietary supplement and as a
peripheral vasodilator to combat aging in humans. In this study, for the very first time, we …

Abstract Chronic Obstructive Pulmonary Disease is a generally smoking-linked major cause
of morbidity and mortality. Genome-wide Association Studies identified a locus including a …

Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk
factors. Although genetic risk variants for individual cancers have been identified, an …

Lung cancer (LC) is the most common global cancer. An individual's risk of developing LC is
mediated by an array of factors, including family history of the disease. Considerable …

Lung cancer is one of the common types of malignant disorders and the most prevalent
cause of cancer-related mortality in the world. Although a wide range of approaches has …

Risk of chronic obstructive pulmonary disease (COPD) is determined by both cigarette
smoking and genetic susceptibility, but little is known about gene-by-smoking interactions …

The complex polygenic nature of lung cancer is not fully characterized. Our study seeks to
identify novel phenotypes associated with lung cancer using cross-trait linkage …