Neurobiological mechanisms of nicotine reward and aversion
Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …
Lung cancer in never smokers: Tumor immunology and challenges for immunotherapy
VTL de Alencar, AB Figueiredo, M Corassa… - Frontiers in …, 2022 - frontiersin.org
Lung cancer is the second most common and the most lethal malignancy worldwide. It is
estimated that lung cancer in never smokers (LCINS) accounts for 10-25% of cases, and its …
estimated that lung cancer in never smokers (LCINS) accounts for 10-25% of cases, and its …
Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking
Z Huang, S Sun, M Lee, AY Maslov, M Shi… - Nature …, 2022 - nature.com
Although lung cancer risk among smokers is dependent on smoking dose, it remains
unknown if this increased risk reflects an increased rate of somatic mutation accumulation in …
unknown if this increased risk reflects an increased rate of somatic mutation accumulation in …
Analyses of rare predisposing variants of lung cancer in 6,004 whole genomes in Chinese
C Wang, J Dai, N Qin, J Fan, H Ma, C Chen, M An… - Cancer Cell, 2022 - cell.com
We present the largest whole-genome sequencing (WGS) study of non-small cell lung
cancer (NSCLC) to date among 6,004 individuals of Chinese ancestry, coupled with 23,049 …
cancer (NSCLC) to date among 6,004 individuals of Chinese ancestry, coupled with 23,049 …
Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study
F Morales Berstein, DL McCartney, AT Lu, KK Tsilidis… - Elife, 2022 - elifesciences.org
Background: Epigenetic clocks have been associated with cancer risk in several
observational studies. Nevertheless, it is unclear whether they play a causal role in cancer …
observational studies. Nevertheless, it is unclear whether they play a causal role in cancer …
Alpha5 nicotinic acetylcholine receptor mediated immune escape of lung adenocarcinoma via STAT3/Jab1-PD-L1 signalling
P Zhu, Z Jin, G Kang, Y Jia, D Liu, Q Zhang… - Cell Communication and …, 2022 - Springer
Background Immunotherapy has proven to be an emerging treatment for non-small-cell lung
cancer in recent years. Notably, smokers show higher programmed cell death ligand-1 (PD …
cancer in recent years. Notably, smokers show higher programmed cell death ligand-1 (PD …
Association between dried fruit intake and pan-cancers incidence risk: A two-sample Mendelian randomization study
C Jin, R Li, T Deng, Z Lin, H Li, Y Yang, Q Su… - Frontiers in …, 2022 - frontiersin.org
Background Observational studies have revealed that dried fruit intake may be associated
with cancer incidence; however, confounding factors make the results prone to be disturbed …
with cancer incidence; however, confounding factors make the results prone to be disturbed …
Genetic analysis of lung cancer and the germline impact on somatic mutation burden
AAG Gabriel, JR Atkins, RCC Penha… - Journal of the …, 2022 - academic.oup.com
Background Germline genetic variation contributes to lung cancer (LC) susceptibility.
Previous genome-wide association studies (GWAS) have implicated susceptibility loci …
Previous genome-wide association studies (GWAS) have implicated susceptibility loci …
Association of Polymorphism CHRNA5 and CHRNA3 Gene in People Addicted to Nicotine
K Chmielowiec, J Chmielowiec… - International Journal of …, 2022 - mdpi.com
Smoking is a chronic and relapsing addictive trait that harms public health. Among the many
identified genetic variants of nicotine dependence, the variants in the CHRNA5/A3/B4 gene …
identified genetic variants of nicotine dependence, the variants in the CHRNA5/A3/B4 gene …
The α5-nAChR/PD-L1 axis facilitates lung adenocarcinoma cell migration and invasion
P Zhu, G Kang, Y Jiao, C Gui, H Fan, X Li, Y Jia… - Human Cell, 2022 - Springer
Abstract α 5 nicotinic acetylcholine receptor (α 5-nAChR) is associated with the progression
of smoking-related lung adenocarcinoma (LUAD), but the molecular mechanism is unclear …
of smoking-related lung adenocarcinoma (LUAD), but the molecular mechanism is unclear …