Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …

Lung cancer is the second most common and the most lethal malignancy worldwide. It is
estimated that lung cancer in never smokers (LCINS) accounts for 10-25% of cases, and its …

Although lung cancer risk among smokers is dependent on smoking dose, it remains
unknown if this increased risk reflects an increased rate of somatic mutation accumulation in …

We present the largest whole-genome sequencing (WGS) study of non-small cell lung
cancer (NSCLC) to date among 6,004 individuals of Chinese ancestry, coupled with 23,049 …

Background: Epigenetic clocks have been associated with cancer risk in several
observational studies. Nevertheless, it is unclear whether they play a causal role in cancer …

Background Immunotherapy has proven to be an emerging treatment for non-small-cell lung
cancer in recent years. Notably, smokers show higher programmed cell death ligand-1 (PD …

Background Observational studies have revealed that dried fruit intake may be associated
with cancer incidence; however, confounding factors make the results prone to be disturbed …

Background Germline genetic variation contributes to lung cancer (LC) susceptibility.
Previous genome-wide association studies (GWAS) have implicated susceptibility loci …

Smoking is a chronic and relapsing addictive trait that harms public health. Among the many
identified genetic variants of nicotine dependence, the variants in the CHRNA5/A3/B4 gene …

Abstract α 5 nicotinic acetylcholine receptor (α 5-nAChR) is associated with the progression
of smoking-related lung adenocarcinoma (LUAD), but the molecular mechanism is unclear …