[HTML][HTML] SCLC: epidemiology, risk factors, genetic susceptibility, molecular pathology, screening, and early detection
We review research regarding the epidemiology, risk factors, genetic susceptibility,
molecular pathology, and early detection of SCLC, a deadly tumor that accounts for 14% of …
molecular pathology, and early detection of SCLC, a deadly tumor that accounts for 14% of …
Mechanisms contributing to the comorbidity of COPD and lung cancer
Lung cancer and chronic obstructive pulmonary disease (COPD) often co-occur, and
individuals with COPD are at a higher risk of developing lung cancer. While the underlying …
individuals with COPD are at a higher risk of developing lung cancer. While the underlying …
[HTML][HTML] Central and peripheral actions of nicotine that influence blood glucose homeostasis and the development of diabetes
Cigarette smoking has long been recognized as a risk factor for type 2 diabetes (T2D),
although the precise causal mechanisms underlying this relationship remain poorly …
although the precise causal mechanisms underlying this relationship remain poorly …
Multifactorial diseases of the heart, kidneys, lungs, and liver and incident cancer: epidemiology and shared mechanisms
C Shi, S de Wit, E Učambarlić… - Cancers, 2023 - mdpi.com
Simple Summary Multifactorial diseases are caused by a combination of genetic and
environmental factors and various risk factors that accumulate with age. Cardiovascular …
environmental factors and various risk factors that accumulate with age. Cardiovascular …
[HTML][HTML] Nicotinic acetylcholine receptor subtype expression, function, and pharmacology: therapeutic potential of α-conotoxins
The pentameric nicotinic acetylcholine receptors (nAChRs) are typically classed as muscle-
or neuronal-type, however, the latter has also been reported in non-neuronal cells. Given …
or neuronal-type, however, the latter has also been reported in non-neuronal cells. Given …
Contribution of the α5 nAChR subunit and α5SNP to nicotine-induced proliferation and migration of human cancer cells
I Papapostolou, D Ross-Kaschitza, F Bochen, C Peinelt… - Cells, 2023 - mdpi.com
Nicotine in tobacco is known to induce tumor-promoting effects and cause chemotherapy
resistance through the activation of nicotinic acetylcholine receptors (nAChRs). Many …
resistance through the activation of nicotinic acetylcholine receptors (nAChRs). Many …
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain
only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage …
only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage …
Global burden of cancers attributable to tobacco smoking, 1990–2019: an ecological study
Aim and background Identifying risk factors for cancer initiation and progression is the
cornerstone of the preventive approach to cancer management and control (EPMA J. 4 (1) …
cornerstone of the preventive approach to cancer management and control (EPMA J. 4 (1) …
Survivin-targeted nanomedicine for increased potency of abiraterone and enzalutamide against prostate cancer
Prostate cancer is the leading and most aggressive cancer around the world, several
therapeutic approaches have emerged but none have achieved the satisfactory result …
therapeutic approaches have emerged but none have achieved the satisfactory result …
[HTML][HTML] Genomic medicine to reduce tobacco and related disorders: translation to precision prevention and treatment
Genomic medicine can enhance prevention and treatment. First, we propose that advances
in genomics have the potential to enhance assessment of disease risk, improve prognostic …
in genomics have the potential to enhance assessment of disease risk, improve prognostic …