The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives
L Wanka, K Iqbal, PR Schreiner - Chemical reviews, 2013 - ACS Publications
A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …
Pharmaceuticals that contain polycyclic hydrocarbon scaffolds
TP Stockdale, CM Williams - Chemical Society Reviews, 2015 - pubs.rsc.org
Numerous variations on structural motifs exist within pharmaceutical compounds that have
entered the clinic. These variations have amounted over many decades based on years of …
entered the clinic. These variations have amounted over many decades based on years of …
Propellanes—from a chemical curiosity to “explosive” materials and natural products
AM Dilmaç, E Spuling, A de Meijere… - Angewandte Chemie …, 2017 - Wiley Online Library
Propellanes are a unique class of compounds currently consisting of well over 10 000
representatives, all featuring two more or less inverted tetrahedral carbon atoms that are …
representatives, all featuring two more or less inverted tetrahedral carbon atoms that are …
Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus
The influenza A virus M2 proton channel (A/M2) is the target of the antiviral drugs
amantadine and rimantadine, whose use has been discontinued due to widespread drug …
amantadine and rimantadine, whose use has been discontinued due to widespread drug …
Viroporins: structure, function and potential as antiviral targets
C Scott, S Griffin - Journal of General Virology, 2015 - microbiologyresearch.org
The channel-forming activity of a family of small, hydrophobic integral membrane proteins
termed 'viroporins' is essential to the life cycles of an increasingly diverse range of RNA and …
termed 'viroporins' is essential to the life cycles of an increasingly diverse range of RNA and …
Put a cork in it: Plugging the M2 viral ion channel to sink influenza
The ongoing threat of seasonal and pandemic influenza to human health requires antivirals
that can effectively supplement existing vaccination strategies. The M2 protein of influenza A …
that can effectively supplement existing vaccination strategies. The M2 protein of influenza A …
Emerging antiviral strategies to interfere with influenza virus entry
E Vanderlinden, L Naesens - Medicinal research reviews, 2014 - Wiley Online Library
Influenza A and B viruses are highly contagious respiratory pathogens with a considerable
medical and socioeconomical burden and known pandemic potential. Current influenza …
medical and socioeconomical burden and known pandemic potential. Current influenza …
Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus
Anti-influenza drugs, amantadine and rimantadine, targeting the M2 channel from influenza
A virus are no longer effective because of widespread drug resistance. S31N is the …
A virus are no longer effective because of widespread drug resistance. S31N is the …
Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus …
Influenza virus infections lead to numerous deaths and millions of hospitalizations each
year. One challenge facing anti-influenza drug development is the heterogeneity of the …
year. One challenge facing anti-influenza drug development is the heterogeneity of the …
Heterocyclic inhibitors of viroporins in the design of antiviral compounds
VA Shiryaev, YN Klimochkin - Chemistry of heterocyclic compounds, 2020 - Springer
Ion channels of viruses (viroporins) represent a common type of protein targets for drugs.
The relative simplicity of channel architecture allows convenient computational modeling …
The relative simplicity of channel architecture allows convenient computational modeling …