Mef2 is a conserved and significant transcription factor in the control of muscle gene
expression. In cell culture Mef2 synergises with MyoD-family members in the activation of …

The MEF2 transcription factors have roles in muscle, cardiac, skeletal, vascular, neural,
blood and immune system cell development through their effects on cell differentiation …

Rationale: The heart undergoes dramatic developmental changes during the prenatal to
postnatal transition, including maturation of cardiac myocyte energy metabolic and …

Anabolic resistance and impaired myocellular quality contribute to age-related sarcopenia,
which exacerbates with obesity. Diet-induced muscle mass loss is attenuated by resistance …

Muscle stem cells undergo a dramatic metabolic switch to oxidative phosphorylation during
differentiation, which is achieved by massively increased mitochondrial activity. Since …

The obesity epidemic represents a critical public health issue worldwide, as it is a vital risk
factor for many diseases, including type 2 diabetes (T2D) and cardiovascular disease …

Proper formation of the mammalian heart requires precise spatiotemporal transcriptional
regulation of gene programs in cardiomyocytes. Sophisticated regulatory networks have …

Abstract Background Long non-coding RNAs (lncRNAs) have been studied extensively over
the past few years. Large numbers of lncRNAs have been identified in mouse, rat, and …

Using Hi-C, promoter-capture Hi-C (pCHi-C), and other genome-wide approaches in
skeletal muscle progenitors that inducibly express a master transcription factor, Pax7, we …

Background Skeletal muscles express a highly specialized proteome that allows the
metabolism of energy sources to mediate myofiber contraction. This muscle-specific …