Metabolic syndrome, which includes diabetes and obesity, is one of the most widespread
medical conditions. It induces systemic inflammation, causing far reaching effects on the …

Inflammation is an integral part of the body's physiological repair mechanism, unless it
remains unresolved and becomes pathological, as evident in the progressive nature of …

Background Although macrophages (MΦ) are known as essential players in wound healing,
their contribution to recovery from spinal cord injury (SCI) is a subject of debate. The …

Central nervous system (CNS) immune privilege is an experimentally defined phenomenon.
Tissues that are rapidly rejected by the immune system when grafted in sites, such as the …

Traumatic brain injury (TBI) is the leading cause of death and disability in young adults in the
developed world. The accuracy of early outcome-prediction remains poor even when all …

The adaptive arm of the immune system has been suggested as an important factor in brain
function. However, given the fact that interactions of neurons or glial cells with T lymphocytes …

Experimental autoimmune encephalomyelitis (EAE) is widely regarded as an animal model
of the human disease multiple sclerosis. A multitude of studies has investigated the …

Mood disorders, despite the widespread availability of monoamine-based antidepressant
treatments, are associated with persistently high rates of disability, together with elevated …

Background Chondroitin sulfate proteoglycan (CSPG) is a major component of the glial scar.
It is considered to be a major obstacle for central nervous system (CNS) recovery after injury …

The well regulated activities of microglia and T cells specific to central nervous system
(CNS) antigens can contribute to the protection of CNS neural cells and their renewal from …