The bioinorganic chemistry of mammalian metallothioneins
The functions, purposes, and roles of metallothioneins have been the subject of
speculations since the discovery of the protein over 60 years ago. This article guides …
speculations since the discovery of the protein over 60 years ago. This article guides …
[HTML][HTML] Metallobiology and therapeutic chelation of biometals (copper, zinc and iron) in Alzheimer's disease: Limitations, and current and future perspectives
Background Alzheimer's disease (AD) is the most prevalent cause of cognitive impairment
and dementia worldwide. The pathobiology of the disease has been studied in the form of …
and dementia worldwide. The pathobiology of the disease has been studied in the form of …
[HTML][HTML] The functions of metamorphic metallothioneins in zinc and copper metabolism
Recent discoveries in zinc biology provide a new platform for discussing the primary
physiological functions of mammalian metallothioneins (MTs) and their exquisite zinc …
physiological functions of mammalian metallothioneins (MTs) and their exquisite zinc …
[HTML][HTML] Copper signalling: causes and consequences
Copper-containing enzymes perform fundamental functions by activating dioxygen (O 2) and
therefore allowing chemical energy-transfer for aerobic metabolism. The copper …
therefore allowing chemical energy-transfer for aerobic metabolism. The copper …
Neurotoxicity linked to dysfunctional metal ion homeostasis and xenobiotic metal exposure: redox signaling and oxidative stress
Significance: Essential metals such as copper, iron, manganese, and zinc play a role as
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …
N‐Terminal Cu‐Binding Motifs (Xxx‐Zzz‐His, Xxx‐His) and Their Derivatives: Chemistry, Biology and Medicinal Applications
P Gonzalez, K Bossak, E Stefaniak… - … A European Journal, 2018 - Wiley Online Library
Peptides and proteins with N‐terminal amino acid sequences NH2‐Xxx‐His (XH) and NH2‐
Xxx‐Zzz‐His (XZH) form well‐established high‐affinity CuII‐complexes. Key examples are …
Xxx‐Zzz‐His (XZH) form well‐established high‐affinity CuII‐complexes. Key examples are …
Iron, copper, and zinc concentration in Aβ plaques in the APP/PS1 mouse model of Alzheimer's disease correlates with metal levels in the surrounding neuropil
SA James, QI Churches, MD de Jonge… - ACS chemical …, 2017 - ACS Publications
The metal ions of iron, copper, and zinc have long been associated with the aggregation of β-
amyloid (Aβ) plaques in Alzheimer's disease; an interaction that has been suggested to …
amyloid (Aβ) plaques in Alzheimer's disease; an interaction that has been suggested to …
Copper imbalance in Alzheimer's disease: Convergence of the chemistry and the clinic
In this perspective we list the many clinical, histopathological, genetic and chemical
observations relating copper to Alzheimer's disease (AD). We summarize how the …
observations relating copper to Alzheimer's disease (AD). We summarize how the …
[HTML][HTML] Mammalian metallothionein-3: New functional and structural insights
M Vašák, G Meloni - International journal of molecular sciences, 2017 - mdpi.com
Metallothionein-3 (MT-3), a member of the mammalian metallothionein (MT) family, is mainly
expressed in the central nervous system (CNS). MT-3 possesses a unique neuronal growth …
expressed in the central nervous system (CNS). MT-3 possesses a unique neuronal growth …
[HTML][HTML] Mutual interference of Cu and Zn ions in Alzheimer's disease: perspectives at the molecular level
E Atrián-Blasco, A Conte-Daban, C Hureau - Dalton transactions, 2017 - pubs.rsc.org
While metal ions such as copper and zinc are essential in biology, they are also linked to
several amyloid-related diseases, including Alzheimer's disease (AD). Zinc and copper can …
several amyloid-related diseases, including Alzheimer's disease (AD). Zinc and copper can …