The renin-angiotensin system (RAS) is undisputedly one of the most prominent endocrine
(tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) vasoactive …

Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from
a binding site with unknown function to a firmly established major effector within the …

The cardiovascular and other actions of angiotensin II (Ang II) are mediated by AT1 and AT2
receptors, which are seven transmembrane glycoproteins with 30% sequence similarity …

The renin-angiotensin system (RAS) is a coordinated hormonal cascade in the control of
cardiovascular, renal, and adrenal function that governs body fluid and electrolyte balance …

Background Renal renin-angiotensin system (RAS) activation is one of the important
pathogenic mechanisms in the development of diabetic nephropathy in type 2 diabetes. The …

Angiotensin II (Ang II), the biologically active component of renin-angiotensin system (RAS),
acts through two receptor subtypes, the AT1 and the AT2 receptor. All classic physiological …

AT1R (angiotensin type 1 receptor) and AT2R (angiotensin type 2 receptor) are well known
to be involved in the complex cardiovascular actions of AngII (angiotensin II). However …

The first druglike selective angiotensin II AT2 receptor agonist (21) with a K i value of 0.4 nM
for the AT2 receptor and a K i> 10 μM for the AT1 receptor is reported. Compound 21, with a …

Angiotensin II (Ang II) is considered the major final mediator of the renin-angiotensin system.
The actions of Ang II have been implicated in many cardiovascular conditions, such as …

The renin angiotensin system (RAS) is intricately involved in normal cardiovascular
homeostasis. Excessive stimulation by the octapeptide angiotensin II contributes to a range …