Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

The proposed curative properties of Cu-based non-steroidal anti-inflammatory drugs
(NSAIDs) have led to the development of numerous Cu (II) complexes of NSAIDs with …

Objective A 2‐year randomized controlled trial was performed to test the hypothesis that
long‐term, continuous treatment with nonsteroidal antiinflammatory drugs (NSAIDs), in …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs in
inflammatory diseases, since they are effective in management of pain, fever, redness …

Rheumatoid arthritis, juvenile idiopathic arthritis, the seronegative spondyloarthropathies
including psoriatic arthritis, and systemic lupus erythematosus are all examples of rheumatic …

Objectives: To provide an overview on: 1) the expression of cyclooxygenase (COX)-2 in
articular tissues; 2) the role of prostaglandin E2 (PGE2) in these tissue functions; and 3) …

Objective To examine cyclooxygenase‐2 (COX‐2) enzyme expression, its regulation by
interleukin‐1β (IL‐1β), and the role of prostaglandin E2 (PGE2) in proteoglycan degradation …

Background Axial spondyloarthritis (axSpA) comprises ankylosing spondylitis (radiographic
axSpA) and non‐radiographic (nr‐) axSpA and is associated with psoriasis, uveitis and …

Current evidence suggests that two forms of prostaglandin (PG) E synthase (PGES),
cytosolic PGES and membrane-bound PGES (mPGES)-1, preferentially lie downstream of …

Background The antiinflammatory, analgesic, and antipyretic actions of aspirin became well
known during the years after its introduction. More recently, the beneficial effects of the …