Genome-wide association studies (GWAS) originally identified ATP-binding cassette, sub-
family A, member 7 (ABCA7), as a novel risk gene of Alzheimer's disease (AD). Since then …

Alzheimer's disease (AD)(MIM: 104300) is a highly heritable disease with great complexity
in its genetic contributors, and represents the most common form of dementia. With the …

Single-cell transcriptomics provide a systematic map of gene expression in different human
cell types. The next challenge is to systematically understand cell-type-specific gene …

Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging
population and society as a whole. With the numbers of people with ADRDs predicted to rise …

To understand how neural-immune-associated genes and pathways contribute to
neurodegenerative disease pathophysiology, we performed a systematic functional genomic …

The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously
associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune …

High density lipoprotein (HDL) cholesterol has traditionally been considered the “good
cholesterol”, and most of the research regarding HDL cholesterol has for decades revolved …

Alzheimer's disease (AD) is a neurodegenerative disorder that leads to age‐related
cognitive and sensori‐motor dysfunction. There is an increased understanding that motor …

Aims The association of plasma high-density lipoprotein (HDL) cholesterol with risk of
dementia is unclear. We, therefore, tested the hypothesis that high levels of plasma HDL …

Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease for
which the genetic contribution is incompletely understood. Methods We conducted a joint …