Three ATP-binding cassette (ABC)-superfamily multidrug efflux pumps are known to be
responsible for chemoresistance; P-glycoprotein (ABCB1), MRP1 (ABCC1) and ABCG2 …

Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

Background Pharmacogenetic determinants of the response of patients to clopidogrel
contribute to variability in the biologic antiplatelet activity of the drug. The effect of these …

ABCB1 (MDR1) is one of many ubiquitous adenosine triphosphate (ATP)-binding cassette
(ABC) genes present in all kingdoms of life that is responsible for cellular homeostasis [1–3] …

Flavonoids are polyphenols that are found in numerous edible plant species. Data obtained
from preclinical and clinical studies suggest that specific flavonoids are chemo-preventive …

Resistance to drug treatment is an important hurdle in the therapy of many brain disorders,
including brain cancer, epilepsy, schizophrenia, depression and infection of the brain with …

1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …

Worldwide, colorectal cancer (CRC) is the third most common cancer, with the highest
mortality rates occurring in Central Europe. The use of chemotherapy to treat CRC is limited …

Despite the lack of sufficient information on the safety of herbal products, their use as
alternative and/or complementary medicine is globally popular. There is also an increasing …

Accumulation of amyloid-β (Aβ) within extracellular spaces of the brain is a hallmark of
Alzheimer disease (AD). In sporadic, late-onset AD, there is little evidence for increased Aβ …