[HTML][HTML] CRISPR-based diagnostics
MM Kaminski, OO Abudayyeh, JS Gootenberg… - Nature Biomedical …, 2021 - nature.com
The accurate and timely diagnosis of disease is a prerequisite for efficient therapeutic
intervention and epidemiological surveillance. Diagnostics based on the detection of nucleic …
intervention and epidemiological surveillance. Diagnostics based on the detection of nucleic …
[HTML][HTML] Current applications and future perspective of CRISPR/Cas9 gene editing in cancer
SW Wang, C Gao, YM Zheng, L Yi, JC Lu, XY Huang… - Molecular cancer, 2022 - Springer
Clustered regularly interspaced short palindromic repeats (CRISPR) system provides
adaptive immunity against plasmids and phages in prokaryotes. This system inspires the …
adaptive immunity against plasmids and phages in prokaryotes. This system inspires the …
[HTML][HTML] CRISPR/Cas9 therapeutics: progress and prospects
T Li, Y Yang, H Qi, W Cui, L Zhang, X Fu, X He… - Signal transduction and …, 2023 - nature.com
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases …
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases …
Recent advancements in molecular marker-assisted selection and applications in plant breeding programmes
Background DNA markers improved the productivity and accuracy of classical plant
breeding by means of marker-assisted selection (MAS). The enormous number of …
breeding by means of marker-assisted selection (MAS). The enormous number of …
Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants
The number and diversity of known CRISPR–Cas systems have substantially increased in
recent years. Here, we provide an updated evolutionary classification of CRISPR–Cas …
recent years. Here, we provide an updated evolutionary classification of CRISPR–Cas …
A catalog of tens of thousands of viruses from human metagenomes reveals hidden associations with chronic diseases
Despite remarkable strides in microbiome research, the viral component of the microbiome
has generally presented a more challenging target than the bacteriome. This gap persists …
has generally presented a more challenging target than the bacteriome. This gap persists …
[HTML][HTML] Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects
H Li, Y Yang, W Hong, M Huang, M Wu… - Signal transduction and …, 2020 - nature.com
Based on engineered or bacterial nucleases, the development of genome editing
technologies has opened up the possibility of directly targeting and modifying genomic …
technologies has opened up the possibility of directly targeting and modifying genomic …
CRISPR–Cas9 gRNA efficiency prediction: an overview of predictive tools and the role of deep learning
The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated
protein 9 (Cas9) system has become a successful and promising technology for gene …
protein 9 (Cas9) system has become a successful and promising technology for gene …
Rapid evolutionary turnover of mobile genetic elements drives bacterial resistance to phages
Although it is generally accepted that phages drive bacterial evolution, how these dynamics
play out in the wild remains poorly understood. We found that susceptibility to viral killing in …
play out in the wild remains poorly understood. We found that susceptibility to viral killing in …
CRISPR/Cas systems towards next-generation biosensing
Beyond its remarkable genome editing ability, the CRISPR/Cas9 effector has also been
utilized in biosensing applications. The recent discovery of the collateral RNA cleavage …
utilized in biosensing applications. The recent discovery of the collateral RNA cleavage …