Sphingolipids and their metabolites play key cellular roles both as structural components of
membranes and as signaling molecules that mediate responses to physiologic cues and …

Ectopic lipids play a key role in numerous pathologies, including heart disease, stroke, and
diabetes. Of all the lipids studied, perhaps the most well understood is cholesterol, a widely …

Parkinson's disease (PD) is a progressive neurodegenerative disorder, which is
characterised by degeneration of distinct neuronal populations, including dopaminergic …

Fungal infections cause more than 1.5 million deaths annually. With an increase in immune-
deficient susceptible populations and the emergence of antifungal drug resistance, there is …

Misfolded proteins in the endoplasmic reticulum (ER) are removed through a process known
as ER-associated degradation (ERAD). ERAD occurs through an integral membrane protein …

Thraustochytrids are marine protists highly ecologically relevant in mangrove environments.
The family Thraustochytriaceae underwent profound taxonomical rearrangements in the last …

In eukaryotic cells, the endoplasmic reticulum (ER) is a major site of synthesis of both lipids
and proteins, many of which must be transported to other organelles. The COPII coat …

The endoplasmic reticulum is the site of synthesis of most glycerophospholipids, neutral
lipids and the initial steps of sphingolipid biosynthesis of the secretory pathway. After …

Cholesterol plays a key role in many cellular processes, and is generated by cells through
de novo biosynthesis or acquired from exogenous sources through the uptake of low-density …

A general principle in all cells in the body is that an essential metal–here copper–is taken up
at the plasma membrane, directed through cellular compartments for use in specific …