Precision medicine for obesity: current evidence and insights for personalization of obesity pharmacotherapy

D Anazco, A Acosta - International Journal of Obesity, 2024 - nature.com
Obesity is a chronic and complex disease associated with increased morbidity, mortality,
and financial burden. It is expected that by 2030 one of two people in the United States will …

Type-2 diabetes mellitus remission prediction models after Roux-En-Y gastric bypass and sleeve gastrectomy based on disease severity scores

W Ghusn, K Hage, RA Vierkant… - Diabetes Research and …, 2024 - Elsevier
Aim Metabolic and bariatric surgery (MBS) is considered one of the most effective
interventions for weight loss and associated type-2 diabetes mellitus (T2DM) remission …

Type 2 Diabetes Remission in Patients with Heterozygous Variants in the Leptin-Melanocortin Pathway after Roux-en-Y Gastric Bypass: A Matched Case–Control …

D Anazco, W Ghusn, A Campos, L Cifuentes, S Fansa… - Obesity Surgery, 2023 - Springer
Background Roux-en-Y gastric bypass (RYGB) is associated with a high rate of type 2
diabetes (T2D) remission. Carriers of heterozygous variants in the leptin-melanocortin …

Leptin‐Melanocortin pathway variants and gastric emptying in patients with obesity

L Cifuentes, W Ghusn, A Campos… - …, 2024 - Wiley Online Library
Background Accelerated gastric emptying (GE) is a trait seen in obesity. Mutations in the
hypothalamic leptin‐melanocortin 4 receptor (Leptin‐MC4R) pathway have been associated …

The association between microvascular and macrovascular diseases and diabetes remission after bariatric surgery

W Ghusn, M Salame, L Sayegh, K Hage, AC Storm… - Surgical …, 2024 - Springer
Background Type-2 diabetes mellitus (T2DM) results in detrimental vascular complications
including both microvascular and macrovascular diseases. Roux-en-Y gastric bypass …