Alcohol and cancer: epidemiology and biological mechanisms

H Rumgay, N Murphy, P Ferrari, I Soerjomataram - Nutrients, 2021 - mdpi.com
Approximately 4% of cancers worldwide are caused by alcohol consumption. Drinking
alcohol increases the risk of several cancer types, including cancers of the upper …

[HTML][HTML] The oralome and its dysbiosis: New insights into oral microbiome-host interactions

A Radaic, YL Kapila - Computational and structural biotechnology journal, 2021 - Elsevier
The oralome is the summary of the dynamic interactions orchestrated between the
ecological community of oral microorganisms (comprised of up to approximately 1000 …

European white paper: oropharyngeal dysphagia in head and neck cancer

LWJ Baijens, M Walshe, LM Aaltonen, C Arens… - European Archives of …, 2021 - Springer
Abstract Purpose To develop a European White Paper document on oropharyngeal
dysphagia (OD) in head and neck cancer (HNC). There are wide variations in the …

Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy

AA Bhat, P Yousuf, NA Wani, A Rizwan… - Signal transduction and …, 2021 - nature.com
Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor
prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have …

Tobacco use and oral health

PJ Ford, AM Rich - Addiction, 2021 - Wiley Online Library
This review outlines the important oral implications of tobacco use. The lining of the mouth
(oral mucosa), if exposed to tobacco and its products in a susceptible individual, can …

Global incidence trends in head and neck cancer for HPV-related and-unrelated subsites: A systematic review of population-based studies

F dos Santos Menezes, GA Fernandes, JLF Antunes… - Oral oncology, 2021 - Elsevier
In head and neck cancer (HNC), some subsites are associated with human papillomavirus
(HPV) infection, whereas others are unrelated. Although studies have demonstrated the …

The key differences between human papillomavirus-positive and-negative head and neck cancers: biological and clinical implications

SF Powell, L Vu, WC Spanos, D Pyeon - Cancers, 2021 - mdpi.com
Simple Summary Head and neck cancer (HNC) is the sixth most common cancer, causing
almost half a million deaths worldwide every year. The two subtypes of HNC are distinctly …

[HTML][HTML] Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions

JS Gutkind, AA Molinolo, X Wu, Z Wang… - JCI insight, 2021 - ncbi.nlm.nih.gov
BACKGROUND The aberrant activation of the PI3K/mTOR signaling circuitry is one of the
most frequently dysregulated signaling events in head and neck squamous cell carcinoma …

Impacts of environmental factors on head and neck cancer pathogenesis and progression

M Miranda-Galvis, R Loveless, LP Kowalski, Y Teng - Cells, 2021 - mdpi.com
Epidemiological and clinical studies over the past two decades have provided strong
evidence that genetic elements interacting with environmental components can individually …

Survival of dental implants and occurrence of osteoradionecrosis in irradiated head and neck cancer patients: a systematic review and meta-analysis

DJ Toneatti, RR Graf, JP Burkhard, B Schaller - Clinical oral investigations, 2021 - Springer
Objectives This systematic review assesses dental implant survival, calculates the incidence
rate of osteoradionecrosis, and evaluates risk factors in irradiated head and neck cancer …