During recent decades there have been remarkable advances in biology, in which one of
the most important discoveries is RNA interference (RNAi). RNAi is a specific post …

Since the discovery of the human immunodeficiency virus (HIV) in 1983, dramatic progress
has been made in the development of novel antiviral drugs. The HIV epidemic fuelled the …

Significant effort has been applied to discover and develop vehicles which can guide small
interfering RNAs (siRNA) through the many barriers guarding the interior of target cells …

RNA interference (RNAi) is an evolutionarily conserved defence mechanism whereby genes
are specifically silenced through degradation of messenger RNAs; this process is mediated …

Hepatitis C virus (HCV) will continue to be a serious global health threat for many years to
come because of the chronic nature of the infection, its high prevalence and the significant …

Proteolytic Processing of Structural Proteins Proteolytic Processing of Nonstructural Proteins
Cis-Acting RNA Sequences Required for Replication Mechanism of RNA Replication …

Gene silencing using short interfering RNA (siRNA) is fast becoming an attractive approach
to probe gene function in mammalian cells. Although there have been some success in the …

RNA interference (RNAi) is a conserved sequence-specific, gene-silencing mechanism that
is induced by double-stranded RNA. RNAi holds great promise as a novel nucleic acid …

The burden of disease consequent to hepatitis C virus (HCV) infection has been well
described and is expected to increase dramatically over the next decade. Current approved …

Recently a cell culture model supporting the complete life cycle of the hepatitis C virus
(HCV) was developed. Searching for host cell determinants involved in the HCV replication …