Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …

Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of
treatment failure and relapsing infections. They are thus important drivers of increased …

SUMMARY β-Lactam antibiotics have been widely used as therapeutic agents for the past
70 years, resulting in emergence of an abundance of β-lactam-inactivating β-lactamases …

Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Public health interventions to control the current epidemic of carbapenem-resistant
Klebsiella pneumoniae rely on a comprehensive understanding of its emergence and …

Due to their superior tolerability and efficacy, β-lactams are the most potent and prescribed
class of antibiotics in the clinic. The emergence of resistance to those antibiotics, mainly due …

ABSTRACT β-Lactamases, the major resistance determinant for β-lactam antibiotics in Gram-
negative bacteria, are ancient enzymes whose origins can be traced back millions of years …

Klebsiella pneumoniae is a Gram-negative opportunistic pathogen responsible for a variety
of community and hospital infections. Infections caused by carbapenem-resistant K …

Bacterial pathogens as causative agents of infection constitute an alarming concern in the
public health sector. In particular, bacteria with resistance to multiple antimicrobial agents …

The concept of the antibiotic resistome was introduced just over a decade ago, and since
then, active resistome studies have been conducted. In the present study, we describe the …