Preventing and controlling influenza virus infection remains a global public health
challenge, as it causes seasonal epidemics to unexpected pandemics. These infections are …

Viroporins are small, hydrophobic proteins that are encoded by a wide range of clinically
relevant animal viruses. When these proteins oligomerize in host cell membranes, they form …

The M2 protein from influenza A virus is a pH-activated proton channel that mediates
acidification of the interior of viral particles entrapped in endosomes. M2 is the target of the …

The influenza A virus was isolated for the first time in 1931, and the first attempts to develop
a vaccine against the virus began soon afterwards. In addition to causing seasonal …

The influenza A virus M2 proton channel (A/M2) is the target of the antiviral drugs
amantadine and rimantadine, whose use has been discontinued due to widespread drug …

Voltage-gated proton channels (HV) are unique, in part because the ion they conduct is
unique. HV channels are perfectly selective for protons and have a very small unitary …

The successful isolation of a human influenza virus in 1933 was soon followed by the first
attempts to develop an influenza vaccine. Nowadays, vaccination is still the most effective …

Influenza A virus (IAV) uses the low pH in late endocytic vacuoles as a cue for penetration by
membrane fusion. Here, we analyzed the prefusion reactions that prepare the core for …

Influenza viruses infect a wide range of avian and mammalian host species including
humans. Influenza viruses are a major cause of human respiratory infections and mortality …

The ongoing threat of seasonal and pandemic influenza to human health requires antivirals
that can effectively supplement existing vaccination strategies. The M2 protein of influenza A …