Abstract MCL1 (myeloid cell leukemia-1) is a widely recognized pro-survival member of the
Bcl-2 (B-cell lymphoma protein 2) family and a promising target for cancer therapy. While the …

It is often assumed that an animal's metabolic rate can be estimated through measuring the
whole-organism oxygen consumption rate. However, oxygen consumption alone is unlikely …

Cardiovascular disease (CVD) affects one in three adults and remains the leading cause of
death in America. Advancing age is a major risk factor for CVD. Recent plateaus in CVD …

Aims Arrhythmogenic cardiomyopathy (ACM) is characterized by progressive loss of
cardiomyocytes, and fibrofatty tissue replacement. Extracellular vesicles (EVs) secreted by …

During postnatal cardiac development, cardiomyocytes mature and turn into adult ones.
Hence, all cellular properties, including morphology, structure, physiology and metabolism …

This study sought to investigate the effects of mechanical unloading on myocardial
energetics and the metabolic perturbation of heart failure (HF) in an effort to identify potential …

Rationale: Mitochondria play a dual role in the heart, responsible for meeting energetic
demands and regulating cell death. Paradigms have held that mitochondrial fission and …

Peripheral artery disease (PAD) is an atherosclerotic disease that impairs blood flow and
muscle function in the lower limbs. A skeletal muscle myopathy characterized by …

Providing a conducive microenvironment is critical to increase survival of transplanted stem
cells in regenerative therapy. Hyperglycemia promotes stem cell death impairing cardiac …

Skeletal muscle, which accounts for approximately 40% of total body weight, is one of the
most dynamic and plastic tissues in the human body and plays a vital role in movement …