Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. Discovered 30
years ago, it is produced as a consequence of alternative RNA processing of the calcitonin …

Nerve growth factor (NGF) is a neurotrophic protein essential for the growth, differentiation,
and survival of sympathetic and sensory afferent neurons during development. A substantial …

Although nutrient-starvation therapies can elicit strong anti-tumor effects in multiple
carcinomas, it has been convincingly demonstrated that cancer cells exploit the tumor …

Mast cells are best recognized for their role in allergy and anaphylaxis, but increasing
evidence supports their role in neurogenic inflammation leading to pain and itch. Mast cells …

There is growing interest in the complex relationship between the nervous and immune
systems and how its alteration can affect homeostasis and result in the development of …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Importance Patients with osteoarthritis (OA) may remain symptomatic with traditional OA
treatments. Objective To assess 2 subcutaneous tanezumab dosing regimens for OA …

Are there sex differences in pain? For experimentally delivered somatic stimuli, females
have lower thresholds, greater ability to discriminate, higher pain ratings, and less tolerance …

This review focuses on the role of the peripheral nervous system in cutaneous biology and
disease. During the last few years, a modern concept of an interactive network between …

The transient receptor potential (TRP) superfamily of cation channels contains four
temperaturesensitive channels, named TRPV1–4, that are activated by heat stimuli from …