15-lipoxygenase and cyclooxygenase expression profile and their related modulators in COVID-19 infection
S Kianfar, V Salimi, A Jahangirifard, SB Mirtajani… - … and Essential Fatty …, 2023 - Elsevier
Background The role of the lipoxygenase (LOX) and cyclooxygenase (COX) enzymes in
maintaining cellular homeostasis and regulating immune responses promoted us in this
study to analyze the pattern of changes in 15-lipoxygenase and cyclooxygenase isoforms
and their related cytokines in SARS-CoV-2 infection. Methods 15-LOX-1, 15-LOX-2, COX-1
and COX-2 gene expression levels were determined using qRT-PCR in nasopharynx
specimens from patients with severe [N= 40] and non-severe [N= 40] confirmed SARS-CoV …
maintaining cellular homeostasis and regulating immune responses promoted us in this
study to analyze the pattern of changes in 15-lipoxygenase and cyclooxygenase isoforms
and their related cytokines in SARS-CoV-2 infection. Methods 15-LOX-1, 15-LOX-2, COX-1
and COX-2 gene expression levels were determined using qRT-PCR in nasopharynx
specimens from patients with severe [N= 40] and non-severe [N= 40] confirmed SARS-CoV …
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