A TCR β-chain motif biases toward recognition of human CD1 proteins
High-throughput TCR sequencing allows interrogation of the human TCR repertoire,
potentially connecting TCR sequences to antigenic targets. Unlike the highly polymorphic
MHC proteins, monomorphic Ag-presenting molecules such as MR1, CD1d, and CD1b
present Ags to T cells with species-wide TCR motifs. CD1b tetramer studies and a survey of
the 27 published CD1b-restricted TCRs demonstrated a TCR motif in humans defined by the
TCR β-chain variable gene 4-1 (TRBV4-1) region. Unexpectedly, TRBV4-1 was involved in …
potentially connecting TCR sequences to antigenic targets. Unlike the highly polymorphic
MHC proteins, monomorphic Ag-presenting molecules such as MR1, CD1d, and CD1b
present Ags to T cells with species-wide TCR motifs. CD1b tetramer studies and a survey of
the 27 published CD1b-restricted TCRs demonstrated a TCR motif in humans defined by the
TCR β-chain variable gene 4-1 (TRBV4-1) region. Unexpectedly, TRBV4-1 was involved in …
