A common polymorphism in the SCN1A gene associates with phenytoin serum levels at maintenance dose
SK Tate, R Singh, CC Hung, JJ Tai… - Pharmacogenetics …, 2006 - journals.lww.com
Objectives A broad range of phenytoin doses is used in clinical practice, with the final
'maintenance'dose normally determined by trial and error. A common functional
polymorphism in the SCN1A gene (one of the genes encoding the drug target) has been
previously associated with maximum dose of phenytoin used clinically, and also maximum
dose of carbamazepine, another antiepileptic drug with the same drug target. Methods We
have related variation at the SCN1A IVS5− 91 G> A polymorphism to maximum dose and to …
'maintenance'dose normally determined by trial and error. A common functional
polymorphism in the SCN1A gene (one of the genes encoding the drug target) has been
previously associated with maximum dose of phenytoin used clinically, and also maximum
dose of carbamazepine, another antiepileptic drug with the same drug target. Methods We
have related variation at the SCN1A IVS5− 91 G> A polymorphism to maximum dose and to …
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