Innate immunity comprises evolutionarily conserved self-defense mechanisms against
microbial infections. In mammals, innate immunity interacts with adaptive immunity and has
a key role in the regulated immune response. Therefore, innate immunity is a
pharmaceutical target for the development of immune regulators. Using Drosophila ex vivo
culture systems, we isolated a cyclopentanediol analogue from Aspergillus sp. as an
immunosuppressive substance. This compound selectively suppressed activation of the IMD …

A cyclopentanediol analogue selectively suppresses the conserved innate immunity
pathways, Drosophila IMD and TNF-α pathways. | CiNii Research … A cyclopentanediol
analogue selectively suppresses the conserved innate immunity pathways, Drosophila IMD
and TNF-α pathways. … タイトル A cyclopentanediol analogue selectively suppresses the
conserved innate immunity pathways, Drosophila IMD and TNF-α pathways. …