A difference in sensitivity to alpha-adrenergic agonists exhibited by detrusor and bladder neck of rabbit

JW Downie, DM Dean, G Carro-Ciampi… - Canadian Journal of …, 1975 - cdnsciencepub.com
JW Downie, DM Dean, G Carro-Ciampi, SA Awad
Canadian Journal of Physiology and Pharmacology, 1975cdnsciencepub.com
In cumulative dose–response studies, strips from bladder neck of rabbit were significantly
more sensitive to stimulation with noradrenaline, phenylephrine, and methoxamine than
were strips from detrusor. There was no difference between the two regions in sensitivity to
isoprenaline or carbachol. From the known characteristics of these agents, it seemed
unlikely that metabolic destruction or uptake could account for the different sensitivities seen.
Also, neither normetanephrine nor desmethylimipramine could alter significantly the potency …
In cumulative dose–response studies, strips from bladder neck of rabbit were significantly more sensitive to stimulation with noradrenaline, phenylephrine, and methoxamine than were strips from detrusor. There was no difference between the two regions in sensitivity to isoprenaline or carbachol. From the known characteristics of these agents, it seemed unlikely that metabolic destruction or uptake could account for the different sensitivities seen. Also, neither normetanephrine nor desmethylimipramine could alter significantly the potency of noradrenaline in either area of the bladder. It seems likely that the difference in sensitivity to alpha-adrenoceptor stimulation in the bladder neck and detrusor is due to factors at the receptor level.
Canadian Science Publishing
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