… In a double-blind clinical trial comprising 29 depressed patients citalopram, a highly
selective 5-HT re-uptake inhibitor and maprotiline, a specific NA reuptake inhibitor, were
compared. … This study attempts to assess the therapeutic efficacy and the side-effects of
citalopram as compared with those of maprotiline, a frequently used antidepressant. Maprotiline
has been shown to have similar clinical effects as standard tricyclic antidepressants (Klein
et al., 1980a) with, however, a generally favourable side-effect profile (Dessain et al., 1986). …