Zhadin and Barnes [2005:26:323–330] concluded that they solved the differential equation describing combined action of DC and AC magnetic fields on thermal motion of ions in a biological macromolecule and, as a result, a diversity of biological phenomena could be explained. It is shown here that biological phenomena cannot be explained based on this model. Adair [2006:27:332–334] gave several arguments for the statement that the interaction of weak magnetic fields with ions trapped in protein cavities cannot produce detectable biological effects through changing the character of the ion orbits. The arguments are analyzed here and some are shown to be questionable or unjustified. We stress the difference between the conclusion made by Adair and that stated in this article. Bioelectromagnetics 28:409–412, 2007. © 2007 Wiley‐Liss, Inc.