Appropriate axon guidance is necessary to form accurate neuronal connections. Axon
guidance cues that stimulate cytoskeletal reorganization within the growth cone direct axon
navigation. Filopodia at the growth cone periphery have long been considered sensors for
axon guidance cues, yet how they respond to extracellular cues remains ill defined. Our
previous work found that the filopodial actin polymerase VASP and consequently filopodial
stability are negatively regulated via nondegradative TRIM9-dependent ubiquitination …

Appropriate axon guidance is necessary to form accurate neuronal connections. Guidance
cues stimulate reorganization of the cytoskeleton within the distal growth cone at the tip of
the extending axon. Filopodia at the periphery of the growth cone have long been
considered sensors for axon guidance cues, yet how they perceive and respond to
extracellular cues remains ill-defined. Our previous work found that the filopodial actin
polymerase VASP is regulated via TRIM9-dependent nondegradative ubiquitination, and …