A pilot dose-finding clinical trial of creatine monohydrate augmentation to SSRIs/SNRIs/NASA antidepressant treatment in major depression
B Nemets, J Levine - International clinical psychopharmacology, 2013 - journals.lww.com
Creatine's effects on brain energy metabolism raise the possibility of developing a new
therapeutic strategy in depression focusing on the treatment of metabolic hypoactive brain
areas. Previous creatine augmentation studies in patients with major depression showed a
beneficial effect. Eighteen patients (14 women) with major depression not responding to
previous 3 weeks of antidepressant treatment were enrolled into a pilot, dose finding, 4-
week double-blind parallel augmentation study where creatine monohydrate 5 or 10 g daily …
therapeutic strategy in depression focusing on the treatment of metabolic hypoactive brain
areas. Previous creatine augmentation studies in patients with major depression showed a
beneficial effect. Eighteen patients (14 women) with major depression not responding to
previous 3 weeks of antidepressant treatment were enrolled into a pilot, dose finding, 4-
week double-blind parallel augmentation study where creatine monohydrate 5 or 10 g daily …
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