A prospective study of the risk of congenital defects associated with maternal obesity and diabetes mellitus

LL Moore, MR Singer, ML Bradlee, KJ Rothman… - …, 2000 - journals.lww.com
This study was designed to evaluate the effects of maternal obesity and diabetes mellitus on
the risk of nonchromosomal congenital defects. We used data from 22,951 pregnant women
enrolled in a prospective cohort study of early prenatal exposures and pregnancy outcome.
The relative risks [prevalence ratios (PRs)] of major nonchromosomal congenital defects
associated with obesity and diabetes, alone or in combination, were calculated using
multiple logistic regression analysis. In this study, in the absence of diabetes, obese women …
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