Calcium and cyclic nucleotides have crucial roles in mammalian fertilization, but the
molecules comprising the Ca2+-permeation pathway in sperm motility are poorly
understood. Here we describe a putative sperm cation channel, CatSper, whose amino-acid
sequence most closely resembles a single, six-transmembrane-spanning repeat of the
voltage-dependent Ca2+-channel four-repeat structure. CatSper is located specifically in the
principal piece of the sperm tail. Targeted disruption of the gene results in male sterility in …

A sperm ion channel required for sperm motility and male fertility. - Abstract - Europe PMC …
A sperm ion channel required for sperm motility and male fertility. … Catsper3 and Catsper4
are essential for sperm hyperactivated motility and male fertility in the mouse. …