A spontaneous mutation in DNA polymerase POL3 during in vitro passaging causes a hypermutator phenotype in Cryptococcus species
Passaging of microbes in vitro can lead to the selection of microevolved derivatives with
differing properties to their original parent strains. One well characterised instance is the
phenotypic differences observed between the series of strains derived from the type strain of
the human pathogenic fungus Cryptococcus neoformans. A second case was reported in the
close relative Cryptococcus deneoformans, in which a well-studied isolate ATCC 24067
(52D) altered its phenotypic characteristics after in vitro passaging in different laboratories …
differing properties to their original parent strains. One well characterised instance is the
phenotypic differences observed between the series of strains derived from the type strain of
the human pathogenic fungus Cryptococcus neoformans. A second case was reported in the
close relative Cryptococcus deneoformans, in which a well-studied isolate ATCC 24067
(52D) altered its phenotypic characteristics after in vitro passaging in different laboratories …
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