[HTML][HTML] Absence of a gestational diabetes phenotype in the LepRdb/+ mouse is independent of control strain, diet, misty allele, or parity
Abstract Treatment options for gestational diabetes (GDM) are limited. In order to better
understand mechanisms and improve treatments, appropriate animal models of GDM are
crucial. Heterozygous db mice (db/+) present with glucose intolerance, insulin resistance,
and increased weight gain during, but not prior to, pregnancy. This makes them an ideal
model for GDM. However, several recent studies have reported an absence of GDM
phenotype in their colony. We investigated several hypotheses for why the phenotype may …
understand mechanisms and improve treatments, appropriate animal models of GDM are
crucial. Heterozygous db mice (db/+) present with glucose intolerance, insulin resistance,
and increased weight gain during, but not prior to, pregnancy. This makes them an ideal
model for GDM. However, several recent studies have reported an absence of GDM
phenotype in their colony. We investigated several hypotheses for why the phenotype may …
以上显示的是最相近的搜索结果。 查看全部搜索结果