Absorption difference between hepatotoxic pyrrolizidine alkaloids and their N-oxides–Mechanism and its potential toxic impact

M Yang, J Ma, J Ruan, C Zhang, Y Ye, PPC Fu… - Journal of …, 2020 - Elsevier
Abstract Ethnopharmacological relevance Pyrrolizidine alkaloids (PAs) are a group of
phytotoxins widely present in about 3% of flowering plants. Many PA-containing herbal
plants can cause liver injury. Our previous studies demonstrated that PA N-oxides are also
hepatotoxic, with toxic potency much lower than the corresponding PAs, due to significant
differences in their toxicokinetic fates. Aim of study This study aimed to investigate the oral
absorption of PAs and PA N-oxides for better understanding of their significant differences in …

Absorption difference between hepatotoxic pyrrolizidine alkaloids and their N-oxides - mechanism and its potential toxic impact.

YMB Yang MengBi, MJ Ma Jiang, RJQ Ruan JianQing… - 2020 - cabidigitallibrary.org
Abstract Ethnopharmacological relevance: Pyrrolizidine alkaloids (PAs) are a group of
phytotoxins widely present in about 3% of flowering plants. Many PA-containing herbal
plants can cause liver injury. Our previous studies demonstrated that PA N-oxides are also
hepatotoxic, with toxic potency much lower than the corresponding PAs, due to significant
differences in their toxicokinetic fates. Aim of study: This study aimed to investigate the oral
absorption of PAs and PA N-oxides for better understanding of their significant differences in …
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