Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry: implications for drug addiction, sleep and pain
S Ferré, I Diamond, SR Goldberg, L Yao… - Progress in …, 2007 - Elsevier
Adenosine A2A receptors localized in the dorsal striatum are considered as a new target for
the development of antiparkinsonian drugs. Co-administration of A2A receptor antagonists
has shown a significant improvement of the effects of l-DOPA. The present review
emphasizes the possible application of A2A receptor antagonists in pathological conditions
other than parkinsonism, including drug addiction, sleep disorders and pain. In addition to
the dorsal striatum, the ventral striatum (nucleus accumbens) contains a high density of A2A …
the development of antiparkinsonian drugs. Co-administration of A2A receptor antagonists
has shown a significant improvement of the effects of l-DOPA. The present review
emphasizes the possible application of A2A receptor antagonists in pathological conditions
other than parkinsonism, including drug addiction, sleep disorders and pain. In addition to
the dorsal striatum, the ventral striatum (nucleus accumbens) contains a high density of A2A …
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